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Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the United States.  Although the incidence and mortality from colon cancer have been on a slow decline over the past two decades, an estimated 93,090 individuals will be diagnosed with colon cancer in the US in 2015, and combined estimates for colon and rectal cancer are 49,700 deaths in 2015.  Worldwide, CRC is the second most common cancer in women and the third most common in men. The incidence of CRC is relatively equal between men and women.