The best described risk factors for this disease is tobacco use. Smokers are more than twice as likely to get bladder cancer compared to nonsmokers. Chemical exposure have been associated to bladder cancer and that includes dye, paint manufacturing, printing etc. There is also genetic predisposition for those individuals who have Lynch syndrome also known as hereditary nonpolyposis colorectal cancer syndrome as well as Cowden disease. Other conditions that increase the risk of bladder cancer is prior chemotherapy use like cyclophosphamide, prior radiation exposure, chronic bladder infections and irritation.