Translational Research In Oncology-US, Inc. (TRIO-US) is a site management organization (SMO) made up of a committed group of community oncologists interested in participating in translational research studies. TRIO-US also provides protocol development and project management services for investigator initiated trials to be conducted at UCLA and/or the TRIO-US Network. The TRIO-US Network consists of more than 15 community oncology practices across multiple states, a majority in Southern California, responsible for executing clinical trials brought to them by the UCLA Clinical Research Unit (CRU). Many of the TRIO-US Network sites have participated in clinical trials with UCLA since the inception of the network over 20 years ago. UCLA provides the TRIO-US administrative staff with central study activities including regulatory, pharmacy, contracts and billing.