There is no screening program for lymphoma. It is only diagnosed when patients presents with persistent signs and symptoms. A thorough investigation includes taking a history, a physical examination, laboratory tests, scans (CT scans that show the size of tumor masses and PET scans that show how active a lymphoma may grow), and biopsies.
Lymphoma is diagnosed by a lymph node biopsy followed by an examination under the microscope and specialty tests such as immune-phenotyping, flow cytometry, fluorescence in situ hybridization testing, and gene-mutation testing.
These tests should be done by an expert hemato-pathologist very experienced in the diagnosis of lymphoid/hematological malignancies. This is highly relevant as treatments for different lymphoma sub-types differ. In order to maximize cure rates and improve outcomes a correct, precise diagnosis and an appropriate treatment plan are absolutely necessary.